CBD interacts with the body's endocannabinoid system (ECS), a complex cell-signalling system involved in maintaining homeostasis or balance. The ECS is composed of receptors, endocannabinoids, and enzymes that work together to regulate various physiological processes, such as mood, sleep, appetite, and pain sensation.
CBD influences the CB1 and CB2 receptors, indirectly modulating their activity and providing potential therapeutic benefits. Besides ECS, CBD interacts with many different receptors: FAAH, GPR55, 5-HT1A, Adenosine A1, Adenosine A2A, MOR and DOR, TRPV1, Sodium channels, Calcium channels, PPARγ, Dopamine D2. Due to this property CBD is often categorized as a “promiscuous molecule”, which also makes CBD a molecule with great potential in treatment of various conditions.